Lung Cancer Cell Lines

The cells are used as models for the study of lung cancer and the development of drug therapies against it.

Lung cancer cell lines.

Cancer cell lines with mutant kras genes the heterogeneity of human cancers is a major obstacle to developing therapies. Name tissue cell type disease oganism age ethnicity genes expressed crl 5844 nci h838 h838 lung. One way of dealing with that heterogeneity is to test large numbers of patient derived cell lines for common vulnerabilities. Physiologically relevant controls.

A549 cells are adenocarcinomic human alveolar basal epithelial cells and constitute a cell line that was first developed in 1972 by d. Standard of care first line treatment for extensive stage small cell lung cancer is platinum chemotherapy carboplatin or cisplatin with etoposide. Although human lung tumor derived cell lines play an important role in the investigation of lung cancer biology and genetics there is no comprehensive study comparing the genotypic and phenotypic properties of lung cancer cell lines with those of the individual tumors from which they were derived. Browse squamous cell adenocarcinoma sclc and nsclc cell lines for drug response toxicology in vitro models including a549 nci h292 and more.

Non small cell lung cancer is an umbrella term for several types of lung cancers. 1 3 despite response rates of 60 to 65. By default data for all cell lines will be retrieved though search results can be restricted by panels or cell lines in the next part of the form. Lymph node 3b adenocarcinoma.

We produced six murine lung cancer lines capable of orthotopic lung tumor formation in immunocompetent c57bl 6 animals. Lung cancer and normal cell lines atcc no. We compared a variety of properties of 12 human non small cell lung carcinoma nsclc cell lines. When you inhale cigarette smoke which is full of cancer causing substances carcinogens changes in the lung tissue begin almost immediately.

Lung cancer cell lines eml4 alk fusion a549 a549. Atcc provides both primary and htert immortalized bronchial epithelial cells and small airway cells that may be used side by side with nsclc or sclc cells as normal controls. Non small cell lung cancer. Doctors believe smoking causes lung cancer by damaging the cells that line the lungs.

All experiments should include physiologically relevant controls. Once tumors demonstrated growth in a non self host cell lines were established. Successful cell lines were evaluated for the ability to produce orthotopic lung tumors in immunocompetent hosts. Select lung cancer cell lines authenticated by ecacc based on associated mutations and diagnosis classifications.